Encoding the Local Connectivity Patterns of fMRI for Cognitive State Classification

In this work, we propose a novel framework to encode the local connectivity patterns of brain, using Fisher Vectors (FV), Vector of Locally Aggregated Descriptors (VLAD) and Bag-of-Words (BoW) methods. We first obtain local descriptors, called Mesh Arc Descriptors (MADs) from fMRI data, by forming local meshes around anatomical regions, and estimating their relationship within a neighborhood. Then, we extract a dictionary of relationships, called brain connectivity dictionary by fitting a generative Gaussian mixture model (GMM) to a set of MADs, and selecting the codewords at the mean of each component of the mixture. Codewords represent the connectivity patterns among anatomical regions. We also encode MADs by VLAD and BoW methods using the k-Means clustering. We classify the cognitive states of Human Connectome Project (HCP) task fMRI dataset, where we train support vector machines (SVM) by the encoded MADs. Results demonstrate that, FV encoding of MADs can be successfully employed for classification of cognitive tasks, and outperform the VLAD and BoW representations. Moreover, we identify the significant Gaussians in mixture models by computing energy of their corresponding FV parts, and analyze their effect on classification accuracy. Finally, we suggest a new method to visualize the codewords of brain connectivity dictionary.